Analysis performed on 2024-09-30 10:31:11
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 48049 | 735 | 47314 | 26571 |
| Archaea | 3644 | 161 | 3483 | 1423 |
| Vertebrata | 1288 | 502 | 786 | 240 |
| Mammals | 700 | 153 | 547 | 132 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 1264 | 36 | 958 |
| Domains | |
|---|---|
| Current Study | 1, 278 |
| Guo et al (2010) | 2, 218 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 987 | 277 | 1264 | 3.563177 |
| Number of Variants | 767 | 227 | 994 | 3.378855 |
| Number of Pathogenic Variants | 29 | 7 | 36 | 4.142857 |
| Number of Benign/Unknown Variants | 738 | 220 | 958 | 3.354545 |
| Fisher exact test | 0.839591 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 1047 | 217 | 1264 | 4.824885 |
| Number of Variants | 806 | 188 | 994 | 4.287234 |
| Number of Pathogenic Variants | 29 | 7 | 36 | 4.142857 |
| Number of Benign/Unknown Variants | 777 | 181 | 958 | 4.292818 |
| Fisher exact test | 1.000000 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 987 | 277 | 0.81 (0.01) | 0.74 (0.01) | 8.373e-01 | 7.402e-01 | 167649.50 | 4.05e-09 |
| Guo et al (2010) | 1047 | 217 | 0.80 (0.01) | 0.74 (0.01) | 8.338e-01 | 7.265e-01 | 138133.00 | 2.66e-07 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.